Doxitran
Doxitran is effective in treatment of a variety of infectious diseases such as diseases caused by Brucella, Pasteurella, Rickettsia;Pulmonary infection, urogenital infection and ophthalmic infections caused by Chlamydiae and Mycoplasma;ENT infections and bronchi (pulmonary) infection caused by Haemophilus influenzae;Gonorrhea Infections caused by Treponema;Cholera caused by Vibrio cholerae;Acnes caused by Propionibacterium acnes and For preventing malaria caused by Plasmodium falciparum.
Therapeutic Class
Dosage Form & Composition
Capsule: Each Doxitran capsule contains Doxycycline 100 mg.
Pack size: box of 10 blisters x 10 capsules.
Pharmacology
Tetracycline antibiotics are protein synthesis inhibitors, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 30S ribosomal subunit in the mRNA translation complex.
Indications
In treatment of a variety of infectious diseases:
- Diseases caused by Brucella, Pasteurella, Rickettsia.
- Pulmonary infection, urogenital infection and ophthalmic infections caused by Chlamydiae.
- Pulmonary infection, urogenital infection and ophthalmic infection caused by Mycoplasma.
- ENT infections and bronchi (pulmonary) infection caused by Haemophilus influenzae.
- Gonorrhea. Infections caused by Treponema.
- Cholera caused by Vibrio cholerae.
- Acnes caused by Propionibacterium acnes.
- For preventing malaria caused by Plasmodium falciparum.
Contra-indications
- Patients known to be hypersensitive to any of the Tetracyclines.
- Pregnancy and lactation.
- Children under 8 years old.
- Serious liver failure patients.
Precautions/Warnings
Avoid the prolonged treatment because of the super-infection.
Stop using the drug when photosensitivity reactions occurs.
Interactions
| Drug | Interaction | Comments |
| Antacids (aluminum-, calcium- or magnesium- containing) | Decreased absorption of doxycycline | Give antacids containing aluminum, calcium, or magnesium 1–2 hours before or after doxycycline |
| Anticoagulants, oral | Decreased plasma prothrombin activity | Monitor PT carefully; adjust anticoagulant dosage as needed |
| Anticonvulsants (carbamazepine, barbiturates, phenytoin) | Possible decreased doxycycline half-life | |
| Bismuth subsalicylate | Decreased absorption of doxycycline | If concomitant use cannot be avoided, give doxycycline at least 2-3 hours before bismuth subsalicylate |
| Hormonal contraceptives | Decreased effectiveness of oral contraceptive | Use of a second form of contraceptive during treatment with doxycycline is advised |
| Iron-containing preparations | Decreased absorption of doxycycline | Give doxycycline 2 hours before or 3 hours after iron-containing preparations |
| Methoxyflurane (no longer commercially available in the US) | Fatal renal toxicity | |
| Penicillins | Decreased efficacy of penicillins | Avoid concomitant use |
| Proton-pump inhibitors | Decreased absorption of doxycycline | |
| Retinoids, oral (e.g., acitretin, isotretinoin) | Additive adverse CNS effect of pseudotumor cerebri (benign intracranial hypertension) | Avoid concomitant use |
| Urinary catecholamine assay | Possible false elevation secondary to interference with fluorescence test |
Adverse Effects
- Reduction of enamel formation.
- Diarrhoea, nausea.
- Urticaria, photosensitivity reactions.
Inform your doctor of any adverse reaction related to drug use.
Dosage & Administration
Normal indications: take the drug in the meal
Adults over 60 kg body weight: 2 capsules a day
Adults under 60 kg body weight: 2 capsules on the first day, followed by a maintenance dose of 1 capsule
Children over 8 years old: 4 mg/kg body weight per day.
Acute gonorrhea:
- Male: 3 capsules on the first day, in 2 divided doses, followed by 2 capsules for 2-4 days.
- Female: 2 capsules a day.
Primary and secondary syphilis: 3 capsules a day, in 3 divided doses for less than 10 days.
Urethra, cervical, rectal inflammations caused by Chlamydia trachomatis: 2 capsules a day for less than 10 days.
Acnes: 1 capsule a day for 10-15 days, then reduce the dose to 1 capsule every 2 days.
For preventing malaria: take 1 capsule 1-2 days before entering the malaria endemic area, then take 1 capsule daily for 4 weeks after leaving the malaria endemic area.
Storage/Handling Recommendations
Store in dry places, below 30ºC, protect from light.
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