Indications
LIZOCAN Kit : Is indicated for the syndromic management of vaginal discharge.(Vaginal Candidiasis) Clinical manifestations range from asymptomatic carriage to severe inflammatory sign and symptoms. Approximately one third of asymptomatic female earners become symptomatic within 6 months.
Typical symptoms include vaginal or introitus itch plus discharge. The classical feature bright red vaginal mucosa and a yellow or green frothy, malodorous discharge are often evident but some cases merely as a mildly inflamed vagina of nonspecific appearance, or even without any abnormalities.
Contra-indications
LIZOCAN Kit: Is contraindicated in patients with known hypersensitivity to this product or any of its ingredients, or to nitroimidazoles or macrolides.
Co-administration of terfenadine and tiapride with fluconazole (in LIZOCAN Kit) is contraindicated.
LIZOCAN Kit is not advocated during pregnancy, lactation and in children.
Precautions/Warnings
Those who develop rashes due to fluconazole (in LIZOCAN Kit) must be monitored closely. Fluconazole (in LIZOCAN Kit) needs to be advocated with due precaution along with oral hypoglycemic, coumarins, phenytoin, cyclosporine, rifampicin, theophylline, astemizole, rifabutin, tacrolimus and short-acting benzodiazepines.
As azithromycin interacts with aluminum and magnesium-containing antacids, digoxin, ergot derivatives, triazolam and drugs metabolized by cytochrome P450 such as carbamazepine, cyclosporine, phenytoin, LIZOCAN Kit must be Coad ministered with care.
Secnidazole also has potential to interact with coumarins and hence LIZOCAN Kit must be Coad ministered with care along with such anticoagulants.
Alcohol beverages must be avoided whilst taking LIZOCAN Kit, and for three days thereafter since simultaneous intake of nitroimidazoles like secnidazole could result in abdominal cramps, flushing, nausea, vomiting, headaches and even psychotic reactions.
Precautions
LIZOCAN Kit: Is to be advocated with due precaution in hepatic and renal disease, and potentially proarrhythmic conditions in view potential of fluconazole and azithromycin to induce liver and kidney dysfunction, and cardiac conduction abnormalities.
LIZOCAN Kit should be advocated with care in diarrhea since azithromycin usage could be associated with pseudomembranous colitis.
