Glipita M is a prescription medication used to manage type 2 diabetes mellitus. It combines two active ingredients:
- Sitagliptin (50 mg): a DPP-4 inhibitor that increases insulin release and decreases glucagon levels in the blood.
- Metformin (500 mg or 1000 mg): a biguanide that reduces glucose production in the liver and improves insulin sensitivity.
💊 Dosage & Administration
- Typical Starting Dose: 1 tablet twice daily with meals.
- Gradual Dose Escalation: Recommended to minimize gastrointestinal side effects associated with metformin.
- Maximum Daily Dosage: 100 mg sitagliptin and 2000 mg metformin.
🩺 Mechanism of Action
- Sitagliptin: Enhances incretin hormones, leading to increased insulin secretion and decreased glucagon release.
- Metformin: Decreases hepatic glucose production and enhances insulin sensitivity.
Together, they provide better control of blood sugar levels.
⚠️ Side Effects
Common:
- Diarrhea
- Nausea
- Vomiting
- Upset stomach
- Headache
- Sore throat
Serious:
- Lactic acidosis (rare but serious)
- Pancreatitis
- Severe allergic reactions
Hypoglycemia may occur, especially when combined with insulin or sulfonylureas.
⚠️ Warnings & Precautions
- Kidney Function: Use with caution in patients with kidney disease; dose adjustment may be necessary.
- Liver Disease: Not recommended for use in patients with liver disease.
- Alcohol Consumption: Avoid excessive alcohol intake as it may increase the risk of lactic acidosis.
- Pregnancy & Breastfeeding: Consult a healthcare provider before use.
- Drug Interactions: Inform your doctor about all medications you are taking to avoid potential interactions.
🏥 Storage
- Conditions: Store in a cool, dry place away from sunlight.
- Packaging: Typically available in blister packs containing 10 tablets.
📌 Summary
Glipita M is an effective oral medication for managing type 2 diabetes mellitus. It combines sitagliptin and metformin to help control blood sugar levels. Always follow your healthcare provider’s instructions regarding dosage and administration. Regular monitoring of blood sugar levels and kidney function is essential during treatment. Maintain a healthy diet and exercise regimen to optimize the benefits of this medication.
If you have any further questions or need additional information, feel free to ask!
